Portfolio

AmberCycle

A materials science company dedicated to ending waste in the fashion industry and creating the ecosystem for circular textiles

Diadem Bio

Diadem Biotherapeutics, Inc. is a platform therapeutics company developing a broad pipeline of first‑in‑class immunotherapies. Diadem is engineering exosomes to be inhalable cell‑specific immune modulators. Exosomes are small, virus‑sized particles released by cells to communicate throughout the body. Leveraging expertise in genetic engineering and scalable bioprocessing, Diadem is developing cell‑secreted nanovesicles precisely engineered to deliver signals that mimic natural cell‑to‑cell signaling. Diadem’s unique approach enables precise modulation of targets that play a role in chronic inflammation, autoimmune diseases and immune control of cancers, addressing some critical unmet clinical needs.

Encellin

Encellin creates Encapsulated Cell Replacement Therapy (EnCRT) devices—their proprietary soft, porous cell “pouches”—that shield therapeutic cells from the immune system while enabling them to release biomolecules and act as “smart molecular factories.” Their lead program targets Type 1 diabetes, with preclinical data showing maintained cell viability and function without fibrosis, and plans to advance to a Phase 1 clinical trial with first-in-human data expected soon

ImYoo

ImYoo was founded to fill this data gap with a patient‑enabled biodiscovery platform that generates scalable, high fidelity, longitudinal data — the essential components for training machine learning models that can predict treatments from biology, enabling more precise and targeted medicine. Our innovative approach brings single‑cell multi‑omic analysis to small blood volumes self‑collected at home. We aim to identify critical markers from longitudinal samples and during key disease events, like autoimmune flares or adverse therapeutic side effects.

Inaru

INARU is a premium, women‑owned chocolate brand based in the Dominican Republic, offering organic, traceable, and ethically produced chocolate—from farm to finished product—through a vertically integrated model that shares profits with farmers and uses only organic, clean ingredients (just cocoa beans and cane sugar)

MiniCircle

MiniCircle offers non-viral, episomal plasmid gene therapy administered via non-invasive subcutaneous injection; therapies are investigational, not FDA-approved, and delivered through licensed international partner clinics. Their program includes Follistatin (FST-344) therapy for increasing lean mass, reducing fat, and lowering epigenetic age—plus upcoming Klotho therapy.

Mitrix Bio

Creating a bioreactor that grows young mitochondria wrapped them in a special coating with receptors to target specific organs, on an industrial scale.

Parallel Bio

The immune system is the master regulator of health and disease. Medicines that target the immune system – called immunotherapies – are the most effective drugs we’ve ever developed, whether it’s a new cancer therapy that rapidly kills tumors or a vaccine that prevents us from getting sick in the first place. Therefore, immunotherapies will be the future of medicine as they continue to be developed and deployed. However, there are significant challenges in discovering new immunotherapies. Using animal models and other models that don’t fully model the human immune system, an inability to model humans at the population level, and the lack of tools to bring these together with computational approaches are stopping us from realizing the full potential of the next generation of medicine.

Petri Bio

Petri develops pre-seed companies attacking the world’s largest problems at the frontier of biology and engineering.

Spira

Spira Inc. produces sustainable, nutrient-rich ingredients using genetically engineered or carefully cultivated spirulina microalgae. Their premium offering includes Electric Sky™—a rare, plant-based blue pigment that can replace synthetic dyes in food, cosmetics, and textiles. Leveraging a global farm network spanning dozens of countries, Spira creates scalable, carbon-negative ingredients that enhance nutrition and reduce environmental impact

Spout Water

Spout Ventures is pioneering consumer access to clean drinking water with its countertop atmospheric water generator. About the size of a standard coffee machine, Spout extracts humidity from the air, producing up to 2.5 gallons of alkaline, mineralized, filtered water per day—without plumbing, bottled water, or municipal supply. Designed with NASA-inspired technology, it delivers sustainable, pure hydration at home while reducing plastic waste.

Trilobia

Trilobio builds the next generation of biology labs—a unified platform combining modular robotics (Trilobots), intelligent operating system (Trilobio OS), and an app-store model for biological protocols. It enables researchers to design, execute, and document experiments with minimal manual effort, solving reproducibility and labor-intensive challenges in biology research.

Undeterred

Undeterred Capital partners with founders building deep tech and bioscience companies, tackling pivotal commercialization challenges. They invest early—often from incorporation through seed stage—and offer hands-on support across technical, operational, regulatory, and market risks to help build enduring, generational ventures.